Molecular and Cellular Biology of Pathogenic Trypanosomatids (Frontiers in Parasitology) (Original PDF from Publisher)

Molecular and Cellular Biology of Pathogenic Trypanosomatids (Frontiers in Parasitology) (Original Buy PDF from Publisher)

Authored by Marcelo Santos da Silva and edited by Maria Isabel N. Cano.

Every year, millions of people living in tropical locations across the world are infected by trypanosomatids, which are parasites that cause Chagas disease, African trypanosomiasis, and leishmaniasis.

According to the World Health Organization, these diseases are classified as neglected tropical diseases since there are no effective vaccinations and the few existing therapies have numerous side effects, in addition to the possibility of evolving drug-resistant parasite strains.

All of these elements offer a huge problem, imposing a significant fiscal burden on public health systems. Many research initiatives have emerged in recent years with the goal of understanding parasitic molecular and cellular biology, parasite-host interactions, disease pathogenesis mechanisms, and molecular mechanisms of drug resistance, all of which are critical for the development of novel anti-parasite treatments and eradication strategies. This volume focuses on developments in trypanosomatid molecular and cellular biology.

Cellular organization during development, genome organization and maintenance, gene expression control, nuclear and kinetoplast DNA replication, DNA damage repair mechanisms, virulence factors and immune evasion, new molecular diagnostic methods, new therapeutic tools, and recombinant vaccine biology are among the topics covered. This monograph will be of interest to undergraduates (premedical and biologists), graduates (master’s and doctoral students), parasitology researchers, and researchers working in adjacent domains.

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